An international group of researchers led by Vanderbilt University (http://news.vumc.org) has discovered for the first time that there are cannabinoid receptors in the amygdala. The amygdala is one of the primary brain regions involved in regulating anxiety and the flight-or-fight response.
The fight-or-flight response, also known as the acute stress response, refers to a physiological reaction that occurs in the presence of something that is terrifying (or perceived as threatening by the brain), either mentally or physically. The response is triggered by the release of hormones that prepare your body to either stay and deal with a threat or to run away to safety.
In response to acute stress, the body's sympathetic nervous system is activated due to the sudden release of hormones. The sympathetic nervous systems stimulate the adrenal glands triggering the release of catecholamines (think neurotransmitters such as epinephrine and dopamine), which include adrenaline and noradrenaline. This results in an increase in heart rate, blood pressure, and breathing rate. After the threat is gone, it can take 20 minutes to hours to recover.
Enter, CBD. CBD interfaces with the body’s own, natural endocannabinoid system (ECS). The ECS is available in about each cell in the body and manages a large number of our bodies’ capacities, including Appetite, Memory, Sleep, Mood and perception of pain. Stress recuperation is one of the endocannabinoid system’s primary purposes.
CBD also binds to a receptor in the brain named by neuroscience researchers as cannabinoid receptor type 1, or CB1. The CB1 receptor exists on the surface of neuron cells and is very closely tied to the fight-or-flight response and the complex array of neurotransmitters that regulate it.
When researchers studied this CB1 receptor, they discovered that when normal neurotransmitters, which exist naturally in the brain, bind to CB1, there was a lower tendency of the brain to initiate the fight-or-flight response in reaction to a threat. Cannabinoids mimic these naturally occurring neurotransmitters in physical molecular-level structure, allowing them to bind to CB1. However, the effects of these binding interactions are much more complex.
CBD likewise communicates with a neurotransmitter called GABA (gamma-aminobutyric corrosive). GABA transfers messages from one brain cell, or neuron, to another; that message usually is “Back off” or “stop pushing.” GABA advises the body when it’s a great opportunity to shut down, and since a huge number of neurons in the cerebrum react to GABA, the impacts include lessening anxiety, quieting the sensory system, assisting with rest, unwinding the muscles.
So how do you use CBD to help with anxiety? There is a wide range of brands to choose from. It’s critical to comprehend your own needs and how you intend to use CBD. Moreover, it is prudent to counsel with an expert before consuming CBD oil for any medical condition, particularly anxiety.
You can take CBD orally, through vaping or in an edible. Each method has its own benefits. Orally and vaping are the top two choices for most people. Vaping is often used for those intense moments that life brings. Orally is generally used as a daily supplement.
Generally speaking, small amounts of CBD are usually needed for reducing anxiety. However, everyone is different and the amount of CBD you will need will vary from person to person. Since low amounts of CBD usually work best, it is advised to start with a low dose (2mg 2 or 3 times a day). Then increasing it 1 or 2mg per dose each week until you start to see results. If anxiety increases, back down your dose and stay there for a while and see how your body responds. Once you know how CBD works for you and how your body responds to it, you can play with your dose. On days you feel particularly anxious, you can take an extra drop or maybe vape an extra puff.
Information here was taken from various sources on good ole google.